Correction to: Estrogen Exerts Neuroprotective Effects in Vascular Dementia Rats by Suppressing Autophagy and Activating the Wnt/?-Catenin Signaling Pathway

Vascular dementia (VD) is a clinical syndrome of acquired cognitive dysfunction caused by various cerebrovascular factors. Estrogen steroid hormone involved in promoting neuronal survival and regulating many signaling pathways. However, the mechanism which it confers neuroprotective effects VD remains unclear. Here, we aimed to investigate effect estrogen on injury impairment rats. Adult female rats were randomly divided into four groups (sham, model, early later treatment) received sham surgery or bilateral ovariectomy permanent occlusion common carotid arteries (BCCAO). The treatment group daily intraperitoneal injections 17?-estradiol (100 µg/kg/day) for 8 weeks starting day after BCCAO. was administered same 1 week Learning memory functions assessed using Morris water maze. Morphological changes within hippocampal CA1 region observed hematoxylin/eosin staining electron microscopy. Expression proteins associated with autophagy detected immunohistochemical Western blot. We found that significantly alleviated damage reduced expression Beclin1 LC3B, indicating suppression autophagy. Moreover, enhanced ?-catenin Cyclin D1, while reducing glycogen synthase kinase 3?, suggesting activation Wnt/?-catenin signaling. These results indicate ameliorates learning deficiencies rats, this may be explained